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pentobarbital will decrease the level or result of darifenacin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.Contraindicated (1)pentobarbital will lower the extent or result of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration. Solid or moderate CYP3